VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Poor virus-specific T-cell responses early after tick-borne encephalitis virus infection correlate with disease severity [Elektronski vir]
    Aregay, Amare ...
    Tick-borne encephalitis virus (TBEV) infection may cause acute central nervous system inflammation varying in clinical manifestations and severity. A possible correlation of TBEV-specific antibody ... and cell-mediated immune responses, shortly after infection, with clinical manifestations, severity and long-term outcome has been poorly investigated. In a cohort of thirty early tick-borne encephalitis (TBE) patients, we assessed the magnitude, specificity and functional properties of TBEV-specific T-cell and antibody responses. These responses early during disease were assessed in view of clinical manifestations, severity and long-term outcome. TBEV-specific T-cell responses to C, E, NS1, and NS5 proteins were significantly lower in patients with severe acute illness than in patients with mild TBE. Lower T-cell responses to E, NS1, and NS5 proteins also correlated with the development of meningoencephalomyelitis. Virus-specific antibody titres early after infection did not correlate with disease severity, clinical manifestations, or long-term outcome in this study, possibly due to the small number of patients of which matching serum and peripheral blood mononuclear cells were available. The findings suggest that virus-specific T cells afford a certain degree of protection against the development of severe TBEV-induced disease.
    Vir: Emerging microbes & infections. - ISSN 2222-1751 (Vol. 13, iss. 1, [article no.] 2317909, 2024, str. 1-10)
    Vrsta gradiva - e-članek
    Leto - 2024
    Jezik - angleški
    COBISS.SI-ID - 189011971

    Povezava(-e):

    https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2317909
    DOI

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