VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Postoperative nausea and vomiting at major otolaryngologic surgery and efficacy of granisetron
    Jurečič, Ana ; Benedik, Janez ; Marn Skok, Sonja
    Introduction: Postoperative nausea and vomiting (PONV) continues to be a common complication of surgery with higher risk in major otolaryngologic surgery. The aim of our pilot study was to evaluate ... this potential risk and efficacy of granisetron. In the second part of the study, relevance of application of the questionnaire for evaluation of the risk for developing PONV was also tested. Methods: In the prospective, randomised pilot study, we observed 20 patients, ASA 13, that were scheduled for major otolaryngologic surgery. They were randomly devided into two groups, granisetron (N=10) and placebo (N=10) group. 5 minutes before induction of anaesthesia, granisetron 1mg was given as an i.v. injection over 30 seconds to ganisetron group. Anaesthesia was in both groups with isoflurane, nitrous oxide, fentanyl and vecuronium. Patients were assesed 24 hours after operation for incidence of nausea, vomiting or both. To those who experienced PONV, a rescue antiemetic was given. In the second part of the study, the questionnaire for evaluation of the risk for developing PONV was applied to 9 patients, ASA 1-3, that were scheduled for major otolaryngologic surgery. For each patient, the questionnaire was filled out and points were added up. If the sum was 7 or more, granisetron 1 mg i.v. as a prophylactic antiemetic was given before surgery. The same postoperative assesment was for these patients as for the first part of the study. Results: In the first part of the study 20% (2/10) ofpatients experienced PONV in the placebo group, whereas no patient experienced PONV in the granisetron group. Both patients who experienced PONV in placebo group received granisetron as a rescue antiemetic, no interventionswere necessary afrer that. In the second part of the study, 66,6%(6/9) did not receive granisetron (sum was 7 or less) and 33,3% (3/9) of patients did (sum of more than 7). In the granisetron group 1 patient experienced nausea. (Abstract trunacted at 2000
    Vir: Proceedings of the 17th anesthesia and ICU symposium "Alpe Adria" : Udine, 24th - 25th September 2004 (Str. 90-94)
    Vrsta gradiva - prispevek na konferenci
    Leto - 2004
    Jezik - angleški
    COBISS.SI-ID - 18923993

Vnos na polico