VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
PDF
  • Prognostic factors for disease-specific survival in 108 patients with Hürthle cell thyroid carcinoma [Elektronski vir] : a single-institution experience
    Petrič, Rok, 1972- ; Gazić, Barbara ; Bešić, Nikola
    Background: Hürthle cell thyroid carcinoma (HCTC) is a rare disease. It is believed that it is more aggressive than follicular thyroid carcinoma. The aim of our study was to identify factors ... associated with disease-specific and disease-free survival. Methods: Altogether, 108 patients with HCTC (26 male, 82 female; median age 62 years; range 19%87 years) treated at our Institute from 1972 to 2011 were included in the present retrospective study. Data on age, clinical and histopathological factors, tumor stage, recurrence, disease-free and disease-specific survival were collected. Univariate analysis was used to identify factors associated with disease-specific survival. Cox%s multivariate regression model was used to identify independent prognostic factors for disease-specific survival. Results: The follow-up period was 1 to 337 (median 105) months. Of 108 patients, 12 (11%) had distant and 8 (7%) had locoregional metastases before primary treatment. Recurrence was diagnosed in 26 cases (24%): locoregional, distant, and both locoregional and distant in 12, 11, and 3 cases, respectively. The 5-year, 10-year, and 20-year disease-specific survival were 96%, 88%, and 67%, respectively. Independent prognostic factors for disease-specific survival were: age of patients at diagnosis, distant metastases and residual tumor after surgery. Conclusion: Long disease-specific survival was found in patients with HCTC younger than 45 years of age without distant metastases and without residual tumor after surgery.
    Vir: BMC cancer [Elektronski vir]. - ISSN 1471-2407
    Vrsta gradiva - e-članek
    Leto - 2014
    Jezik - angleški
    COBISS.SI-ID - 1899643

    Povezava(-e):

    http://www.biomedcentral.com/content/pdf/1471-2407-14-777.pdf
    DOI

Vnos na polico