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Comparison of Wistar vs. Fischer rat in the incidence of 1,2-dimethylhydrazine induced intestinal tumors = Primerjava incidence črevesnih tumorjev povzročenih z 1,2-dimetilhidrazinom med sevoma podgan Wistar in FischerVečerić-Haler, Željka ; Cerar, Anton, 1945-Background. Many investigators have observed differences in the susceptibilityto induce intestinal tumors by 1,2-dimethylhydrazine (DMH) between various strains of rodents. The results are difficult ... to compare because of the different regimes used for induction. The purpose of our study was to evaluate the influence of strain on DMH-induced intestinal tumors between Wistar and Fischer rats. Materials and rreethods. We used 29 Fischer and 30 Wistar male rats that were injected subcutaneously DMH, weekly, at a dosage of 25 mg/kg-body weight for 20 weeks. After 25 weeks from the beginningof the experiment, the animals were sacrificed and autopsied. The complete length of colorectum and all macroscopic changes were examined histologically. Results. The induction of intestinal tumors was 97% in Fischerrats and 100% in Wistar rats. In Wistar rats 184 tumors were found: 133adenomas, 50 tubular adenocarcinomas and 1 signet-cell carcinoma. 77% of careinamas were found in colorectum and 23% in the small intestine. In Fiseherrats, 126 tumors were found: 94 adenomas, 26 tubular adenocarcinomas, 5signet-cell carcinomas and 1 mucinous carcinoma; 42% of carcinomas were foundin the colorectum and 58% in the small intestine. The strain difference in the incidence of all induced tumors was statistically significant (P=0.001). The differences in the occurrence of the malignant and benign tumors was also significant (P<0.001; P=0.011). Extra intestinal tumors were not found. Conclusions. Wistar rats showed greater percentage of colorectal tumors, and also the distribution of tumors in colorectum resembled more the distribution found in human pathology. That is why we reeommend Wistar rat rather than Fischer rat for the research work on the colorectal tumors.Vir: Radiology and oncology. - ISSN 1318-2099 (Letn. 38, št. 3, 2004, str. 227-234)Vrsta gradiva - članek, sestavni delLeto - 2004Jezik - angleškiCOBISS.SI-ID - 19022809
Avtor
Večerić-Haler, Željka |
Cerar, Anton, 1945-
Teme
Intestinal Neoplasms |
Chemically Induced |
Pathology |
Dimethylhydrazines |
Adenocarcinoma |
Adenoma |
Carcinoma, Signet Ring Cell |
Adenocarcinoma, Mucinous |
Neoplasm Staging |
Rats, Wistar |
Rats, Inbred F344 |
Adenokarcinom |
Adenom |
Dimetilhidrazini |
Karcinom kolobarjastih celic |
Črevesne novotvorbe |
Adenokarcinom mucinozni |
Miši seva F344 |
Novotvorba, stadij |
Podgane, Wistar
Vnos na polico
Trajna povezava
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Večerić-Haler, Željka | 37833 |
Cerar, Anton, 1945- | 05367 |
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