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  • Prognostic significance of apoptosis in medulloblastoma
    Pižem, Jože ...
    Since apoptosis is a major contributor to cell loss in medulloblastoma, eitherspontaneous or induced by radiation and chemotherapy, the apoptotic ratein resection specimens could have prognostic ... significance. We analysed theapoptotic rate in 58 medulloblastoma resection specimens using an antibody against cleaved caspase 3, a specific marker of apoptotic cell death, and tested its possible prognostic significance. The apoptotic rate varied considerably among medulloblastomas (0.1-25.9%, median 1.1 %). Apoptotic cellswere relatively evenly distributed in 39 cases, while in 19 cases, an uneven distribution with foci of an increased number of apoptotic cells and their clustering was observed. Clusters of apoptotic cells were found around necrotic areas, while necrotic cells were caspase 3 negative. The apoptotic rate was higher in medulloblastomas with CSF dissemination, tended to be higher in desmoplastic medulloblastomas, but there was no association with agegroup and sex. In the univariate analysis of overall survival, the apoptotic rate had no prognostic value. The variation in apoptotic rate among medulloblastomas is very likely predominantly associated with variations in tumour microenvironment, as supported by apoptotic cell clustering and rimmingaround necrotic areas. The apoptotic rate in medulloblastoma resection specimens does not seem to be of prognostic value.
    Vir: Neuroscience letters. - ISSN 0304-3940 (Letn. 381, 2005, str. 69-73)
    Vrsta gradiva - članek, sestavni del
    Leto - 2005
    Jezik - angleški
    COBISS.SI-ID - 19246553

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