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Skin substitutes [Elektronski vir] : an overview of current state of the artKočivnik, NinaThe skin is the largest organ in the body and performs many physiological functions. Of these, the barrier between the organism and the environment is the most important. Any perturbation of the skin ... can lead to several pathological events, so the main goal of medicine is to repair the damage. In clinical practice, this is most commonly performed either with conventional coverages, which include petroleum gauze and silicone sheets, or biological coverages, which include allografts, xenografts, and human amnion. However, their use is limited in the case of extensive and deep wounds. Skin substitutes from tissue-engineered biomaterials are being developed to overcome these shortcomings. Research studies aim to improve their applicability mainly in terms of meeting relevant clinical requirements (tailored to the wound size and type of skin damage), accessibility, and preparation technique. An ideal biomaterial skin substitute has to be safe for the patient, has proven clinical efficacy, and is convenient for handling and use. At present, none of the available products fulfill all these requirements. In this review, we aim to present the currently available commercial skin substitutes and indications for their use in clinical practice as well as describe their advantages and disadvantages. Also, the latest progress in the development of skin models in the area of achieving vascularization, the incorporation of skin adnexa, and the creation of full-thickness skin are overviewed.Vrsta gradiva - prispevek na konferenci ; neleposlovje za odrasleLeto - 2024Jezik - angleškiCOBISS.SI-ID - 193989379
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Kočivnik, Nina | ![]() |
Vir: Osebne bibliografije
in: SICRIS
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