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  • Survivin is a negative prognostic marker in medulloblastoma
    Pižem, Jože ...
    Survivin is a member of the inhibitor of apoptosis protein family, which is over-expressed in many human cancers. Our aim was to analyse survivin expression in medulloblastoma, its association with ... aberrant activation of theWNT (wingless) pathway and to test the prognostic significance of survivin expression. We immuno histochemically analysed survivinexpression and localization of B-catenin, a downstream mediator of the WNT pathway, in 56 cases of medulloblastoma. Survivin was detected in the nucleiof tumour cells in all cases, but the proportion of positive nuclei varied from 0.5 to 31.3%. Survivin expression tended to be higher in medulloblastomas with an aberrant activation of of the WNT pathway (nuclear localization of B-catenin), but did not correlate with histological type, age group or dissemination via cerebrospinal fluid pathways. Survivin expression and dissemination status were two independent negative prognostic variables for the overall survival ofpatients with medulloblastoma. In conclusion, survivin is up-regulated in medulloblastomas. It is a negative prognostic marker and a potential therapeutic target.
    Vir: Neuropathology and applied neurobiology. - ISSN 0305-1846 (Letn. 31, št. 4, 2005, str. 422-428)
    Vrsta gradiva - članek, sestavni del
    Leto - 2005
    Jezik - angleški
    COBISS.SI-ID - 19884505

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