-
Utilization of ethylcellulose microparticles with rupatadine fumarate in designing orodispersible minitablets with taste masking effect [Elektronski vir]Wasilewska, Katarzyna ...Minitablets in orodispersible form constitute a flexible drug delivery tool for paediatric and geriatric population as they eliminate the risk of chocking and do not require drinking water in the ... application. Due to their direct contact with taste buds, taste sensation is an important factor. Preparing microparticles with taste masking polymers utilizing spray drying is an efficient technique for reducing the bitterness of drugs. Ethylcellulose is a hydrophobic polymer widely used as a taste masking material. Rupatadine fumarate, one of the newest antihistamines, features an intensive bitter taste, hence in designing orodispersible formulations, achieving an acceptable taste is a crucial issue. The main objective of this work was to formulate orodispersible minitablets containing taste masked ethylcellulose-based microparticles with rupatadine fumarate and evaluation of their quality, especially in terms of taste masking efficacy. The accessed data indicated that all obtained minitablets were characterized by beneficial pharmaceutical properties. Three independent methods: in vivo with healthy volunteers, in vitro drug dissolution, and ''electronic tongue'' confirmed that all designed formulations provided satisfactory taste masking rate and that formulation F15 (prepared with Pearlitol Flash and Surelease microparticles with rupatadine fumarate) was characterized by the lowest bitterness score.Vir: Materials [Elektronski vir]. - ISSN 1996-1944 (Vol. 13, iss. 12, 2020, str. 1-21)Vrsta gradiva - e-članek ; neleposlovje za odrasleLeto - 2020Jezik - angleškiCOBISS.SI-ID - 19893507
Povezava(-e):
https://www.mdpi.com/1996-1944/13/12/2715Odprt dostop
Repozitorij Univerze v Ljubljani – RUL
DOI
Avtor
Wasilewska, Katarzyna |
Ciosek-Skibińska, Patrycja |
Lenik, Joanna |
Srčič, Stanko |
Basa, Anna, physical chemist |
Winnicka, K.
Teme
Farmacevtska tehnologija |
Sušenje |
minitablete |
sušenje z razprševanjem |
etilceluloza |
mikrodelci |
prekrivanje okusov |
ruparadin fumarat |
ethylcellulose |
spray drying |
microparticles |
upatadine fumarate |
orodispersible minitablets |
taste masking |
polymers
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|---|
Wasilewska, Katarzyna | |
Ciosek-Skibińska, Patrycja | |
Lenik, Joanna | |
Srčič, Stanko | 09031 |
Basa, Anna, physical chemist | |
Winnicka, K. |
Izberite prevzemno mesto:
Prevzem gradiva po pošti
Obvestilo
Gesla v Splošnem geslovniku COBISS
Izbira mesta prevzema
Mesto prevzema | Status gradiva | Rezervacija |
---|
Prosimo, počakajte trenutek.