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  • Case report: multiple prolactinomas in a young man with Kallmann syndrome and familial hypocalciuric hypercalcemia [Elektronski vir]
    Jensterle Sever, Mojca, 1979- ...
    We present a Caucasian male patient who was diagnosed with Kallmann syndrome (KS) at age 15 years. Testosterone treatment was started. At age 26 the patient presented with mild headache. MRI revealed ... two separate pituitary adenomas along with the absence of the olfactory bulbs. Given the presence of marked hyperprolactinemia (17x upper limit of the reference range) the diagnosis prolactinoma was made and treatment with cabergoline was started which resulted in a complete biochemical response and in marked reduction of both adenomas in size. Hypogonadism persisted and testosterone replacement therapy was continued. Genetic testing of genes associated with pituitary tumors, Kallmann syndrome and idiopathic hypogonadotropic hypogonadism was negative. Mild concomitant hypercalcemia in accordance with familial hypocalciuric hypercalcemia (FHH) prompted mutation analysis of the calcium receptor (CASR) gene which yielded a pathogenic inactivating variant
    Vir: Frontiers in endocrinology [Elektronski vir]. - ISSN 1664-2392 (Vol. 14, 30 okt. 2023, str. 1-7)
    Vrsta gradiva - e-članek
    Leto - 2023
    Jezik - angleški
    COBISS.SI-ID - 199111939

    Povezava(-e):

    https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1248231/full
    DOI

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