VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Flavonoids to reduce bleeding and pain after stapled hemorrhoidopexy: a randomized controlled trial = Flavonoide zur Verminderung von Schmerzen und Blutungen nach Stapler-Haemorrhoidektomie
    Mlakar, Boštjan, 1972- ; Košorok, Pavle
    Introduction: Control of postoperative symptoms is of paramount importance in ambulatory surgery. This trial was conducted to evaluate whether a micronized purified flavonoid fraction (MPFF) ... (Detralex) reduces postoperative bleeding, pain and consumption of analgesics after ambulatory stapled hemorrhoidopexy, as reported in trials after classic hemorrhoidectomy. Phlebotropic activity, protective effect on the capillaries and anti-inflammatory properties of this drug have been reported in several studies. METHODS: Sixty-three patients withthird-degree hemorrhoids had ambulatory stapled hemorrhoidopexy under spinal anesthesia in the period of one year. The patients were randomized, with 30 receiving Detralex 500 mg (2 tablets 3 times daily for 5 days after the operation) and 33 forming the control group. The patients were asked to daily self-assess the presence of blood on defecation, degree of pain and consumption of analgesics for the first week after the operation. RESULTS: There was no significant difference between the two groups in duration of presence of blood, degree of pain or analgesics requirement. No major complications, such as bleeding requiring transfusion or hospitalization, sepsis, anal stenosis or urgent defecation, were noted in the follow-up period. There were no side effects from Detralex treatment. DISCUSSION: In ourstudy we could not demonstrate any positive effect of prescribing flavonoids after stapler hemorrhoidopexy. This procedure may not be sufficiently aggressive and is associated with too few postoperative complications to show any protective influence of flavonoids.
    Vir: Wiener Klinische Wochenschrift. - ISSN 0043-5325 (Jg. 117, hft. 15-16, 2005, str. 558-560)
    Vrsta gradiva - članek, sestavni del
    Leto - 2005
    Jezik - angleški
    COBISS.SI-ID - 20117209

vir: Wiener Klinische Wochenschrift. - ISSN 0043-5325 (Jg. 117, hft. 15-16, 2005, str. 558-560)