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  • Men, testosterone and Covid-19
    Groti Antonič, Kristina ...
    Men have more severe Coronavirus disease 2019 (Covid-19) outcomes and higher mortality rates than women, and it was suggested that testosterone levels might promote severe acute respiratory syndrome ... coronavirus 2 (SARS-CoV-2) infection and Covid-19 severity. However, clinical studies have not supported this theory. Studies have consistently shown that serum testosterone concentrations during acute Covid-19 in men are inversely proportional to the inflammatory cytokines and severity of illness. It is likely that lower testosterone concentrations in this setting are a result of acute Covid-19 illness on the hypothalamic-pituitary-testicular axis. Clinical trials that attempted to lower testosterone concentrations further or block androgen signaling acutely during Covid-19 in men did not result in improved Covid-19 outcomes. Additionally, pre-existing male hypogonadism, diagnosed before Covid-19 pandemic, was found to be a risk factor for hospitalization from Covid-19. In this review, we also discuss the preclinical and mechanistic studies that have evaluated the role of androgens in SARS-CoV-2 infection and illness. Finally, long-term consequences of Covid-19 on male reproductive health are reviewed. SARS-CoV-2 virus is known to infiltrate testis and induce orchitis in men, but it is unclear if Covid-19 leads to an increase in incidence of male hypogonadism.
    Vir: Clinical endocrinology. - ISSN 0300-0664 (Vol. 100, no. 1, 2024, str. 56-65)
    Vrsta gradiva - članek, sestavni del
    Leto - 2024
    Jezik - angleški
    COBISS.SI-ID - 201676803

    Povezava(-e):

    https://onlinelibrary.wiley.com/doi/epdf/10.1111/cen.14952
    Repozitorij Univerze v Ljubljani – RUL
    DOI

vir: Clinical endocrinology. - ISSN 0300-0664 (Vol. 100, no. 1, 2024, str. 56-65)
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