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Men, testosterone and Covid-19Groti Antonič, Kristina ...Men have more severe Coronavirus disease 2019 (Covid-19) outcomes and higher mortality rates than women, and it was suggested that testosterone levels might promote severe acute respiratory syndrome ... coronavirus 2 (SARS-CoV-2) infection and Covid-19 severity. However, clinical studies have not supported this theory. Studies have consistently shown that serum testosterone concentrations during acute Covid-19 in men are inversely proportional to the inflammatory cytokines and severity of illness. It is likely that lower testosterone concentrations in this setting are a result of acute Covid-19 illness on the hypothalamic-pituitary-testicular axis. Clinical trials that attempted to lower testosterone concentrations further or block androgen signaling acutely during Covid-19 in men did not result in improved Covid-19 outcomes. Additionally, pre-existing male hypogonadism, diagnosed before Covid-19 pandemic, was found to be a risk factor for hospitalization from Covid-19. In this review, we also discuss the preclinical and mechanistic studies that have evaluated the role of androgens in SARS-CoV-2 infection and illness. Finally, long-term consequences of Covid-19 on male reproductive health are reviewed. SARS-CoV-2 virus is known to infiltrate testis and induce orchitis in men, but it is unclear if Covid-19 leads to an increase in incidence of male hypogonadism.Vir: Clinical endocrinology. - ISSN 0300-0664 (Vol. 100, no. 1, 2024, str. 56-65)Vrsta gradiva - članek, sestavni delLeto - 2024Jezik - angleškiCOBISS.SI-ID - 201676803
Avtor
Groti Antonič, Kristina |
Antonič, Blaž |
Caliber, Monica |
Dhindsa, Sandeep
Teme
COVID-19 |
hypogonadism |
SARS-CoV-2 |
testis |
testosterone |
COVID-19 |
hipogonadizem |
SARS-CoV-2 |
moda |
testosteron
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Groti Antonič, Kristina | 51833 |
Antonič, Blaž | ![]() |
Caliber, Monica | ![]() |
Dhindsa, Sandeep | ![]() |
Vir: Osebne bibliografije
in: SICRIS
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