VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Mutations in the hemochromatosis gene (HFE) and multiple sclerosis
    Ristić, Smiljana ...
    In the present study we have investigated whether HFE gene polymorphism may play a role in the disease process of Croatian and Slovenian MS patients and their potential genetic susceptibility to MS. ... We genotyped 314 MS patients and400 healthy controls for the C282Y and H63D mutations by polymerase chain reaction/restriction fragment length polymorphism (PCR-RFLP) analysis. Our results showed no significant differences in the distribution of the two mutations between MS patients and controls, suggesting that HFE polymorphisms do not contribute to the susceptibility to MS. Also, there was no significant correlation between HFE polymorphism and the disease progression index. However, we observed that MS patients carrying the mutant C282Y allele exhibited earlier onset of disease symptom relative to other genotypes, but itwarrants further study in a larger series of MS patients.
    Vir: Neuroscience letters. - ISSN 0304-3940 (Letn. 383, 2005, str. 301-304)
    Vrsta gradiva - članek, sestavni del
    Leto - 2005
    Jezik - angleški
    COBISS.SI-ID - 20198361

vir: Neuroscience letters. - ISSN 0304-3940 (Letn. 383, 2005, str. 301-304)
loading ...
loading ...
loading ...

Vnos na polico