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  • Second primary cancers among 109 000 cases of non-Hodgkin's lymphoma
    Brennan, P. ...
    An analysis of other primary cancers in individuals with non-Hodgkinćs lymphoma (NHL) can help to elucidate this cancer aetiology. In all, 109 451 first primary NHL were included in a pooled analysis ... of 13 cancer registries. The observed numbers of second cancers were compared to the expected numbers derived from the age-, sex-, calendar period- and registry-specific incidence rates. We also calculated the standardised incidence ratios for NHL as a second primary after other cancers. There was a 47% (95% confidence interval 43-51%) overall increase in the risk of a primary cancer after NHL. A stronglysignificant (P<0.001) increase was observed for cancers of the lip, tongue, oropharynx*, stomach, small intestine, colon*, liver, nasal cavity*, lung, soft tissues*, skin melanoma*, nonmelanoma skin*, bladder*, kidney*, thyroid*, Hodgkinćs lymphoma*, lymphoid leukaemia* and myeloid leukaemia. Non-Hodgkinćs lymphoma as a second primary was increased after cancers marked with an asterisk. Patterns of risk indicate a treatment effect for lung, bladder, stomach, Hodgkinćs lymphoma and myeloid leukaemia. Common risk factors may be involved for cancers of the lung, bladder, nasal cavity and forsoft tissues, such as pesticides. Bidirectional effects for several cancer sites of potential viral origin argue strongly for a role for immune suppression in NHL.
    Vir: British Journal of Cancer. - ISSN 0007-0920 (Letn. 93, št. 1, 2005, str. 159-166)
    Vrsta gradiva - članek, sestavni del
    Leto - 2005
    Jezik - angleški
    COBISS.SI-ID - 20337113

vir: British Journal of Cancer. - ISSN 0007-0920 (Letn. 93, št. 1, 2005, str. 159-166)
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