-
Expression of FGFR1-4 in malignant pleural mesothelioma tissue and corresponding cell lines and its relationship to patient survival and FGFR inhibitor sensitivity [Elektronski vir]Vlačić, Gregor ...Malignant pleural mesothelioma (MPM) is a devastating malignancy with limited therapeutic options. Fibroblast growth factor receptors (FGFR) and their ligands were shown to contribute to MPM ... aggressiveness and it was suggested that subgroups of MPM patients could benefit from FGFR-targeted inhibitors. In the current investigation, we determined the expression of all four FGFRs (FGFR1-FGFR4) by immunohistochemistry in tissue samples from 94 MPM patients. From 13 of these patients, we were able to establish stable cell lines, which were subjected to FGFR1-4 staining, transcript analysis by quantitative RT-PCR, and treatment with the FGFR inhibitor infigratinib. While FGFR1 and FGFR2 were widely expressed in MPM tissue and cell lines, FGFR3 and FGFR4 showed more restricted expression. FGFR1 and FGFR2 showed no correlation with clinicopathologic data or patient survival, but presence of FGFR3 in 42% and of FGFR4 in 7% of patients correlated with shorter overall survival. Immunostaining in cell lines was more homogenous than in the corresponding tissue samples. Neither transcript nor protein expression of FGFR1-4 correlated with response to infigratinib treatment in MPM cell lines. We conclude that FGFR3 and FGFR4, but not FGFR1 or FGFR2, have prognostic significance in MPM and that FGFR expression is not suffcient to predict FGFR inhibitor response in MPM cell lines.Vir: Cells [Elektronski vir]. - ISSN 2073-4409 (Vol. 8, iss. 9, 2019, str. 1-14)Vrsta gradiva - e-članek ; neleposlovje za odrasleLeto - 2019Jezik - angleškiCOBISS.SI-ID - 2048535409
Avtor
Vlačić, Gregor |
Hoda, Mir Alireza |
Klikovits, Thomas |
Sinn, Katharina |
Gschwandtner, Elisabeth |
Mohorčič, Katja, 1978- |
Schelch, Karin |
Pirker, Christine |
Peter-Vörösmarty, Barbara |
Brankovic, Jelena |
Čufer, Tanja, 1955- |
Rozman, Aleš, 1973- |
Kern, Izidor
Teme
Mesothelioma |
Mesothelioma |
Therapy |
Mesothelioma |
Genetics |
Fibroblast growth factors |
Immunohistochemistry |
Mezoteliom |
Mezoteliom |
Terapija |
Mezoteliom |
Genetika |
Fibroblastni rastni dejavniki |
Imunohistokemija |
maligni plevralni mezoteliom |
receptorji za fibroblastne rastne dejavnike |
azbest |
imunoterapija |
kemoterapija |
genomska analiza |
infigratinib |
malignant pleural mesothelioma |
fibroblast growth factor receptors |
azbestos |
immunotherapy |
chemotherapy |
genomic analysis |
infigratinib
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|---|
Vlačić, Gregor | |
Hoda, Mir Alireza | |
Klikovits, Thomas | |
Sinn, Katharina | |
Gschwandtner, Elisabeth | |
Mohorčič, Katja, 1978- | 30985 |
Schelch, Karin | |
Pirker, Christine | |
Peter-Vörösmarty, Barbara | |
Brankovic, Jelena | |
Čufer, Tanja, 1955- | 12179 |
Rozman, Aleš, 1973- | 25177 |
Kern, Izidor | 15781 |
Izberite prevzemno mesto:
Prevzem gradiva po pošti
Obvestilo
Gesla v Splošnem geslovniku COBISS
Izbira mesta prevzema
Mesto prevzema | Status gradiva | Rezervacija |
---|
Prosimo, počakajte trenutek.