VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Jedrne značilke seroznih tumorjev jajčnika : doktorsko delo
    Strojan Fležar, Margareta
    Image cytometric nuclear texture features (NTF) represent chromatin structure and organisationč therefore, they could be used as a surrogate end-point marker of the chromatin changes during ... neoplastic transformation of cells. Thepurpose of our study was to find out whether, a) a single NTF or a combination of NTF could discriminate between serous borderline malignant ovarian tumors and ovarian carcinomasč b) NTF could discriminate between borderline malignant tumors and different grades or stages of ovarian carcinomač c) different grades or stages in the carcinoma group could also be classified accordingly, using NTF. Finally, we analysed the discriminative power of NTF regarding the survival of the patients with ovarian carcinomas. In our study we analysed NTF of 43 serous borderline malignant tumors and 67 carcinomas of the ovary. Archival tissue samples of ovarian tumors were used for the preparation of single cell suspensions according to the modified Hedleyćs method. Cell monolayer slides were stained according to the Feulgen-thionine method. Image cytometric analysis was performed by using an authomated high resolution image cytometer, namely Cyto-SavantTM. The results of our study showed that a single NTF could discriminate between borderline malignant tumors and carcinomas, whereas an excellent discrimination was achieved using a combination of three NTF (93%). A single NTF could reliably discriminate between borderline malignant tumors and poorly differentiated carcinomas or carcinomas in FIGO stage III and IV, however, the discriminationwas less successful when discriminating borderline malignant tumors from well and moderately differentiated carcinomas or carcinomas in FIGO stage I and II. (Abstract truncated at 2000 characters.)
    Vrsta gradiva - disertacija
    Založništvo in izdelava - Ljubljana : [M. Fležar], 2000
    Jezik - slovenski
    COBISS.SI-ID - 2115092

Knjižnica/institucija Kraj Akronim Za izposojo Druga zaloga
MF, Centralna medicinska knjižnica, Ljubljana Ljubljana CMK na dom 2 izv.
Onkološki inštitut Ljubljana Ljubljana OILJ na dom 2 izv.
Narodna in univerzitetna knjižnica, Ljubljana Ljubljana NUK v čitalnico 1 izv.
Univerzitetna knjižnica Maribor Maribor UKM v čitalnico 1 izv.
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