-
Expression of cyclooxygenase-2 is associated with p53 accumulation in premalignant and malignant gallbladder lesionsLegan, Mateja ...Aim: To examine the relationship between cyclooxygenase-2 (CGX-2) overexpression and p53 accumulation in gallbladder carcinoma and its precursorlesions. Methods: Sixty-eight gallbladder tissue ... samples comprising 14 cases of normal gallblader epithelium, 27 cases of dysplasia (11 low-grade dyplasia and 16 high-grade dysplasia) and 27 adenocarcinomas were evaluated byimmunohistochemistry for COX-2 expression and p53 accumulation. The relationship among COX-2 expression, p53 accumulation and clinicopathological characteristics was analysed. Results: COX-2 was expressed in 14.3% of normal gallbladder epithelium, 70.3% of dysplastic epithelium, and 59.2% of adenocarcinomas. When divided into low- and high-grade dysplasia, COX-2 was positive in 5 (45.4%) cases of low-grade and 14 (87.5%) of highgrade dysplasia(P = 0.019). Accumulation of p53 was detected in 5 (31.2%) cases of high-grade dysplasia and in 13 (48.1%) of carcinomas. No p53 accumulation was found in normal epithelium or low-grade dysplasia. COX-2 overexpression was observed in 17 of 18 (94.4%) cases with p53-accumulation in comparison with 20(40.0%) out of 50 cases without p53 accumulation (P < 0.001). Conclusion: The significant differences in COX-2 expression among normal epithelium, low-grade dysplasia and high-grade dysplasia suggest that overexpression of COX-2 enzyme is an early event in gallbladder carcinogenensis. Furthermore, since accumulation of p53 correlates with COX-2 expression, COX-2 overexpression observed in gallbladder high-grade dysplasia and carcinoma might be partly due to the dysfunction of p53.Vir: World Journal of Gastroenterology = Shijie Wei-Changbingxue Zazhi. - ISSN 1007-9327 (Letn. 12, št. 21, 2006, str. 3425-3429)Vrsta gradiva - članek, sestavni delLeto - 2006Jezik - angleškiCOBISS.SI-ID - 21352665
Avtor
Legan, Mateja |
Luzar, Boštjan |
Ferlan-Marolt, Vera |
Cör, Andrej
Teme
Gallbladder Neoplasms |
Pathology |
Prostaglandin-Endoperoxide Synthase |
Protein P53 |
Adenocarcinoma |
Immunohistochemistry |
Retrospective Studies |
Adenokarcinom |
Beljakovina p53 |
Prostaglandin-endoperoksidna sintaza |
Žolčnik, novotvorbe |
Imunohistokemija |
Retrospektivne študije
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|---|
Legan, Mateja | 12888 |
Luzar, Boštjan | 15472 |
Ferlan-Marolt, Vera | 07192 |
Cör, Andrej | 11308 |
Izberite prevzemno mesto:
Prevzem gradiva po pošti
Obvestilo
Gesla v Splošnem geslovniku COBISS
Izbira mesta prevzema
Mesto prevzema | Status gradiva | Rezervacija |
---|
Prosimo, počakajte trenutek.