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Influence of atorvastatin treatment on L-arginine cerebrovascular reactivity and flow-mediated dilatation in patients with lacunar infarctionsPretnar-Oblak, Janja ...Background and Purpose - In our study we hypothesized that statins improve endothelial function in patients with lacunar infarctions (LI). Cerebral and systemic endothelial function was determined ... before and after 3-months treatment with atorvastatin. Methods-Cerebral endothelial function was determined by L-arginine reactivity and systemic endothelial function by flow-mediated dilatation (FMD) in patients with LI (18 patients, aged 61.1+-7.6 years), 20 age- and gender-matched patients with similar risk factors (SR) and 19 age- and gender-matched healthy controls. The mean arterial velocity (vm) in both middle cerebral arteries was measured by transcranial Doppler sonography before, during and after a 30-minute intravenous infusion of t.-arginine. FMD of the brachial artery after hyperaemia was determined. The measurements were repeated after 3-months treatment with 40 mg of atorvastatin per day. Results- L-arginine reactivity was decreased in LI patients (13.1 +- 8.4%) and in patients with SR compared with healthy controls (P<-0.01). FMD was more impaired in patients with LI (0.06+-4.9%) compared with patients with SR and healthy controls (P<-0.01). After atorvastatin treatment, L-arginine reactivity and FMD improved in both patients with LI (17.1 +-7.6%; 7.0+-5.7%) and patients with SR (P<-0.01). Previously mildly increased cholesterol values normalized. Conclusion-The decreased L-arginine reactivity and FMD improve after atorvastatin treatment in both patients with LI and patients with SR.Vir: Stroke. - ISSN 0039-2499 (Letn. 37, št. 10, 2006, str. 2540-2545)Vrsta gradiva - članek, sestavni delLeto - 2006Jezik - angleškiCOBISS.SI-ID - 21507801
Avtor
Pretnar-Oblak, Janja |
Šabovič, Mišo |
Šebeštjen, Miran |
Pogačnik, Tomaž |
Zaletel, Marjan, 1963-
Teme
Cerebral Infarction |
Drug Therapy |
Endothelium, Vascular |
Drug Effects |
Arginine |
Vasodilation |
Blood Flow Velocity |
Cerebral Arteries |
Ultrasonography, Doppler, Transcranial |
Brachial Artery |
Ultrasonography |
Antilipemic Agents |
Risk Factors |
Arginin |
Endotelij žilni |
Krvni pretok, hitrost |
Možganski infarkt |
Vazodilatacija |
Brahialna arterija |
Dejavniki tveganja |
Lipolitiki |
Možganske arterije |
Ultrasonografija dopplerska, transkranialna
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Pretnar-Oblak, Janja | 16365 |
Šabovič, Mišo | 08094 |
Šebeštjen, Miran | 19345 |
Pogačnik, Tomaž | 05347 |
Zaletel, Marjan, 1963- | 11647 |
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