VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • The X11 proteins, Aß production and Alzheimer's disease
    Miller, Jane Charlotte ...
    Cerebral deposition of amyloid-beta peptide (Abeta) within neuritic plaques isa hallmark pathology of Alzheimer's disease. It is now generally believed that the development of this pathology is ... central to the pathogenesis of Alzheimer's disease. As such, inhibiting Abeta deposition or removing Abeta deposits once they are formed represent therapeutic targets for Alzheimer's disease. Abeta is derived from a precursor, the amyloid precursor protein (APP), and APP binds to the X11 family of adaptor proteins. Studies from several laboratories have now shown that X11alpha and X11beta (the two neuronal X11s) inhibit APP processing and Abeta production. Exactly how this is achieved is not yet known but recent studies in which other X11 binding partners have been identified are beginning to reveal potential mechanisms.
    Vir: Trends in Neurosciences. - ISSN 0166-2236 (Letn. 29, št. 5, 2006, str. 280-285)
    Vrsta gradiva - članek, sestavni del
    Leto - 2006
    Jezik - angleški
    COBISS.SI-ID - 21514713
    DOI

vir: Trends in Neurosciences. - ISSN 0166-2236 (Letn. 29, št. 5, 2006, str. 280-285)
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