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  • Identification and neuropeptide content of trigeminal neurons innervating the rat gingivomucosal tissue
    Gašperšič, Rok, 1972- ...
    Objectives: The purpose of this study was to identify and characterise the neuropeptide content and the size of trigeminal ganglion (TG) neurons innervating the rat gingivomucosal tissue. Design: ... Retrograde nerve tracer Fluorogold (FG) was injected into the gingiva (group 1, n=5) or applied into the gingival sulcus (group 2, n=5) of the first right maxillary molar. After 10 days, the ganglia were dissected and FG fluorescence was observed under UV light microscope. Expression of calcitonin gene-related peptide (CGRP) and substance P (SP) in FG-labelled neurons was investigated by immunohistochemistry. Cross-sectional areas of neuron cell bodies containing FG were determined. As a control group, approximately 1000 neuron cell bodies representing the entire TG neuron population was evaluated in five trigeminal ganglia. Results: In group 1, the percentages of neurons containing CGRP (median 63%, range 48-72%) and SP (median 64%, range 54-64%) were significantly greater than in the control group (CGRP: median 43%, range 42-47% and SP: median 23%, range 21-27%). In group 2, only the percentage of neurons containing SP (median 50%, range 40-56%) was significantly greater than in the control group. FG-labelled neurons were predominantly small or medium sized (less than 1200 microm2). The neurons in the group 1 were significantly smaller than in group 2. In both experimental groups, immunopositive neurons were significantly smaller than immunonegative neurons.Conclusion: The majority of neurons in TG that innervate the rat gingivomucosa are small or medium sized and contain CGRP and SP.
    Vir: Archives of Oral Biology. - ISSN 0003-9969 (Letn. 51, št. 8, 2006, str. 703-709)
    Vrsta gradiva - članek, sestavni del
    Leto - 2006
    Jezik - angleški
    COBISS.SI-ID - 21607129

vir: Archives of Oral Biology. - ISSN 0003-9969 (Letn. 51, št. 8, 2006, str. 703-709)
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