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  • Serum PAPP-A levels at 10-14 weeks of gestation are altered in women after assisted conception
    Tul, Nataša ; Novak-Antolič, Živa
    Objectives: Increased screen-positive rate was observed in the first-trimesterscreening for trisomy 21 (T21) among women after assisted conception. The aim of this study was to identify the trends of ... changes in serum marker levels after different modes of assisted conception. Methods: Retrospectively, we analyzed the levels of free beta human chorionic gonadotrophin (f beta HCG), pregnancy-associated plasma protein-A (PAPP-A) andinhibin A in maternal serum, and fetal nuchal translucency (NT) thickness at 10-14 gestational weeks in 1098 women with singleton pregnancies: 130 afterIVF-ET, 54 after ICSI and 914 after spontaneous conception. Results: In women after IVF-ET and ICSI, PAPP-A was decreased (0.94 MoM and 0.82 MoM, respectively) and inhibin A increased (1.11 MoM and 1.48 MoM, respectively) incomparison to the women after spontaneous conception. With increasing numberof oocytes retrieved PAPP-A decreased and inhibin A increased. In women pregnant after assisted conception without ovarian stimulation (transfer of frozen-thawed embryo or in spontaneous cycle) the marker levels were not significantly different from those in women after spontaneous conception. Conclusions: The presence of multiple corpora lutea may be responsible for thechanges in marker levels. In spite of the differences in marker levels, thescreen-positive rate for T21 is not significantly increased in women after assisted conception.
    Vir: Prenatal diagnosis. - ISSN 0197-3851 (Letn. 26, št. 13, 2006, str. 1206-1211)
    Vrsta gradiva - članek, sestavni del
    Leto - 2006
    Jezik - angleški
    COBISS.SI-ID - 22097369

vir: Prenatal diagnosis. - ISSN 0197-3851 (Letn. 26, št. 13, 2006, str. 1206-1211)
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