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  • Inhibition of biliverdin reductase diminished the protective activity of bilirubin and biliverdin against oxidative stress-induced injury in human vascular endothelium [Elektronski vir]
    Sharma, Kuldeepak ...
    Endothelial dysfunction, a key factor in cardiovascular diseases, is further aggravated by oxidative stress. Biliverdin (BV) and bilirubin (BR) are potent antioxidants that protect endothelial cells, ... with biliverdin reductase (BVR) converting BV to BR to maintain redox balance. This study explored BVR's role in mediating these protective effects under normoxic and hypoxia-reoxygenation conditions. Pharmacological inhibition of BVR reduced the protective effects of BV and BR, as evidenced by decreased cell viability, cellular antioxidant activity, and intracellular bilirubin levels. Activation of ERK1/2 reduced BVR's protective function, while its inhibition enhanced it. Additionally, disruption of the BVR-ERK interaction further modulated these effects, highlighting the BVR-ERK1/2 interaction sites as potential therapeutic targets for oxidative stress-induced endothelial dysfunction.
    Vir: Acta chimica slovenica [Elektronski vir]. - ISSN 1580-3155 (Vol. 71, no. 4, 2024, str. 627-645)
    Vrsta gradiva - e-članek ; neleposlovje za odrasle
    Leto - 2024
    Jezik - angleški
    COBISS.SI-ID - 220977155

    Povezava(-e):

    https://acsi-journal.eu/index.php/ACSi/article/view/8964/10197
    Digitalna knjižnica Slovenije - dLib.si
    Repozitorij Univerze v Ljubljani – RUL
    DOI

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