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  • 8-hydroxyquinoline-based anti-Alzheimer multimodal agents
    Knez, Damijan, farmacevt ...
    The concept of multitarget-directed ligands (MTDLs) has attracted considerable interest in the development of agents against Alzheimer's disease. Cathepsin B, a cysteine protease, and ... butyrylcholinesterase, a serine hydrolase, play important function in the development and progression of Alzheimer's disease. We present herein the evaluation of 8-hydroxyquinoline-based analogues with activities against butyrylcholinesterase and %-secretase activity of cathepsin B. Furthermore, inhibition of amyloid [beta] aggregation, chelation of copper and zinc ions coupled with antioxidative properties and safe cytotoxicity profile of (1R,2S)-N-ethyl-2-[[(8-hydroxy-5-nitroquinolin-7-yl)methyl]amino]cyclohexane-1-carboxamide suggest that this derivative is a good starting point for optimization towards an effective multifunctional ligand.
    Vir: Monatshefte für Chemie = Chemical Monthly. - ISSN 0026-9247 (Vol. 151, 2020, str. 1111-1120)
    Vrsta gradiva - članek, sestavni del
    Leto - 2020
    Jezik - angleški
    COBISS.SI-ID - 22167555

    Povezava(-e):

    https://link.springer.com/article/10.1007/s00706-020-02651-0#citeas
    DOI

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