VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Skin involvement in highly malignant non-Hodgkin lymphomas of childhood and adolescence
    Reich, Adam ...
    Objective: The aim of this study was to demonstrate the clinical spectrum of highly malignant cutaneous non-Hodgkin lymphoma (NHL) in children and to define the outcome among these patients. Material ... and methods: A retrospectiveanalysis of children with NHL treated at Polish oncology centers was carried out in order to determine patients with skin involvement. Thirteensubjects with primary and 4 with secondary cutaneous NHL were studied.The diagnosis of NHL was based on histological and immunohistochemicalexamination of skin biopsy. Results: Nine of 13 cases of primary cutaneous NHL presented as a tumors. Other manifestations were as follows: hard infiltration, edema of subcutaneous tissue, maculopapular lesions, and generalized erythroderma. The mean time between the first cutaneous symptoms and diagnosis of NHL was 5.6 +_ 3.3 months. Secondary cutaneous lesions during the course of NHL were described as maculopapular or nodular eruption. In addition, 2 subjects had generalized ichthyosis. Among patients with primary cutaneous NHL, 11 (84.6%) subjects are still alive without any signs of the disease. Two children (15.4°/o) died. In patients with secondary skin involvement during the course of NHL only one child is still alive with a residual tumor mass in the mediastinum. The estimated 5-year overall survival for primary cutaneous NHL was significantly better than for individuals with secondary cutaneous NHL (p = 0.02). Conclusions: Primary cutaneous NHL has a relatively favorable prognosis. On the other hand,cutaneous metastases of extracutaneous NHL seem to be a poor prognostic factor.
    Vir: Acta dermatovenerologica Alpina, Panonica et Adriatica. - ISSN 1318-4458 (Letn. 15, št. 4, 2006, str. 158-168)
    Vrsta gradiva - članek, sestavni del
    Leto - 2006
    Jezik - angleški
    COBISS.SI-ID - 22327257

    Povezava(-e):

    Digitalna knjižnica Slovenije - dLib.si

Vnos na polico