VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Pomen zaviralcev angiotenzinske konvertaze pri zdravljenju ishemične bolezni srca = The role of ACE inhibitors in the treatment of coronary artery disease
    Šabovič, Mišo
    Inhibitors of angiotensin converting enzyme (ACE inhibitors) are well established in the treatment of arterial hypertension, heart failure and postinfarction dysfunction of the left ventricle. There ... is growing evidence that the renin-angiotensin system also has an important role in the pathogenesis of atherosclerosis and coronary artery disease. Angiotensin II increases oxidative stress and consequent production of free radicals in the arterial wall. It is becoming evident that increased oxidative stress is one of the most important processes in atherosclerosis. Free radicals induce and facilitate endothelial dysfunction, inflammation in the arterial wall and oxidation of LDL cholesterol. Inhibition of angiotensin II decreases its proatherogenic effects. In large clinical trials (HOPE, EUROPA), ACE inhibitors (ramipril, perindopril) were found effective in the prevention of myocardial infarction and st,`-oke, even in patients taking aspirin, statins and beta blockers. This beneficial effect is beyond pressure lowering. Overall, it is clear that treatment with ACE inhibitors is beneficial in patients with manifest atherosclerosis or high risk for it.
    Vir: [Zbornik predavanj] (str. 123-128)
    Vrsta gradiva - prispevek na konferenci
    Leto - 2007
    Jezik - slovenski
    COBISS.SI-ID - 22732505

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