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  • EpoR
    Debeljak, Nataša ; Sytkowski, Arthur J.
    The erythropoietin receptor (EpoR) is a member of the cytokine receptor superfamily and is activated by its native ligand, erythropoietin (Epo). The primary function of Epo is to promote red blood ... cell production by stimulatingerythroid progenitor cell proliferation and differentiation and maintaining viability of the progenitors in the bone marrow. To initiate this process, Epo binds to EpoR on the cell surface. Under normal conditions, the Epo-EpoR interaction is necessary for erythropoiesis to occur. Transgenic micethat lack EpoR exhibited severe anemia and died at embryonic day 13.5. This phenotype could be rescued by expression of human Epo or thrombopoietin (Tpo). Epo also appears to have multiple functions outside of hematopoiesis. Epo and EpoR have been identified on several non-hematopoietic cells and tissues. Epo regulates angiogenesis, is cardio- and neuroprotective, and is suggested to be tissue protective in the gastrointestinal system, reproductivetract and endothelium. EpoRs have been found on several types of tumors and malignant cells. However, research regarding the role of Epo and EpoR in cancer is sometimes contradictory.
    Vir: Nature [Elektronski vir]. - ISSN 1476-4687 (Letn. 425, 2007, str. [1-11])
    Vrsta gradiva - članek, sestavni del
    Leto - 2007
    Jezik - angleški
    COBISS.SI-ID - 23209945

    Povezava(-e):

    http://www.signaling-gateway.org/molecule/query?afcsid=A000863

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