-
Lung tissue and tumour-infiltrating T lymphocytes in patients with non-small cell lung carcinoma and chronic obstructive pulmonary disease (COPD) : moderate/severe versus mild stage of COPDMarc-Malovrh, Mateja ...Cytotoxic CD8+ T cells have been suggested to be key players in the pathogenesis of chronic obstructive pulmonary disease (COPD). We wanted to investigate the phenotype of lung tissue T lymphocytes ... (LTL) and tumour-infiltrating T lymphocytes (TIL) in smokers with peripheral non-small cell lung carcinoma (NSCLC) with moderate/severe versus mild COPD. Lung tissueand tumour samples were obtained from patients with moderate/severe stage of COPD (n = 10) and from patients with mild stage of COPD (n = 7) at lung resection for a solitary peripheral NSCLC, processed and analysed by flowcytometry. The flow-cytometric results showed that lung tissue T cells, regardless of the severity of COPD, were mostly of the activated phenotype, expressed the CXCR3 chemokine receptor characteristic of type 1 T cells, and did neither significantly differ in the expression of activation markers (CD69, CD25 and HLA-DR), differentiation markers (CD27 and CD28) and chemokinereceptors (CXCR3 and CCR4) between the selected groups, nor showed any significant correlation with lung function measured as forced expiratory volume in 1 s (FEV1) or TLCO. Compared with LTL, a significantly greater proportion of TIL expressed the activation markers CD69 and CD25, but a lower proportion showed a fully differentiated CD27- 28- phenotype. We conclude thatlung LTL patterns are similar in NSCLC patients with moderate/severe or mild stages of COPD, and are not significantly related to lung function. LTL and TIL possess different phenotype characteristics. The majority of tumour tissue T cells are activated, but it seems that their process of differentiation is incomplete.Vir: Scandinavian journal of immunology. - ISSN 0300-9475 (Letn. 66, št. 6, 2007, str. 694-702)Vrsta gradiva - članek, sestavni delLeto - 2007Jezik - angleškiCOBISS.SI-ID - 23650265
Avtor
Marc-Malovrh, Mateja |
Korošec, Peter, 1970- |
Kern, Izidor |
Sok, Mihael |
Ihan, Alojz |
Košnik, Mitja
Teme
Lung Neoplasms |
Carcinoma, Non-Small-Cell Lung |
Lung Diseases, Obstructive |
Lymphocytes, Tumor-Infiltrating |
T-Lymphocyte Subsets |
Killer Cells |
Flow Cytometry |
Immunophenotyping |
Karcinom nemalocelični, pljučni |
Limfociti T, podtipi |
Limfociti, tumor-infiltracijski |
Pljučne bolezni obstruktivne |
Pljučne novotvorbe |
Celice ubijalke |
Imunofenotipizacija |
Pretočna citometrija
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|---|
Marc-Malovrh, Mateja | 23464 |
Korošec, Peter, 1970- | 22807 |
Kern, Izidor | 15781 |
Sok, Mihael | 09763 |
Ihan, Alojz | 10337 |
Košnik, Mitja | 10921 |
Izberite prevzemno mesto:
Prevzem gradiva po pošti
Obvestilo
Gesla v Splošnem geslovniku COBISS
Izbira mesta prevzema
Mesto prevzema | Status gradiva | Rezervacija |
---|
Prosimo, počakajte trenutek.