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  • Mitochondrial mediation of environmental osmolytes discrimination during osmoadaptation in the extremely halotolerant black yeast Hortaea werneckii
    Vaupotič, Tomaž ...
    We have investigated the mitochondrial responses to hyperosmotic environments of ionic (4.5M NaCl) and non-ionic (3.0M sorbitol) osmolytes in the most halo/osmo-tolerant black yeast, Hortaea ... werneckii. Adaptation to both types ofosmolytes resulted in differential expression of mitochondria-related genes.Live-cell imaging has revealed a condensation of mitochondria in hyperosmotic media that depends on osmolyte type. In the hypersaline medium, this was accompanied by increased ATP synthesis and oxidative damage protection, whereas adaptation to the non-ionic osmolyte resulted in a decrease in ATP synthesis and lipid peroxidation level in mitochondria. A proteomic study of the mitochondria revealed preferential accumulation of energy metabolism enzymes in the hypersaline medium, and accumulation of protein chaperones in the non-ionic osmolyte. The HwBmh1/14-3-3 protein, localized to mitochondria in hypersaline conditions, and not at optimal salinity, suggesting its role in differential perception of ionic and non-ionic osmolytes in H. werneckii.
    Vir: Fungal genetics and biology. - ISSN 1087-1845 (Issue 6, Vol. 45, 2008, str. 994-1007)
    Vrsta gradiva - članek, sestavni del
    Leto - 2008
    Jezik - angleški
    COBISS.SI-ID - 24000217
    DOI

vir: Fungal genetics and biology. - ISSN 1087-1845 (Issue 6, Vol. 45, 2008, str. 994-1007)
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