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  • Neutrophil and monocyte CD64 and CD163 expression in critically Ill neonates and children with sepsis : comparison of fluorescence intensities and calculated indexes
    Grošelj-Grenc, Mojca ; Ihan, Alojz ; Derganc, Metka
    Objective. To evaluate the expression of CD64 and CD163 on neutrophils and monocytes in SIRS with/without sepsis and to compare the diagnostic accuracy of CD64 and CD163 molecules expression ... determined as (1) mean fluorescence intensities (MFI) of CD64 and CD163; and (2) the ratio (index) of linearized MFI to the fluorescence signal of standardized beads. Patients and methods. Fifty-six critically ill neonates and children with systemic inflammatory response syndrome (SIRS) and suspected sepsis, classified into two groups: SIRS with sepsis (n=29) and SIRS without sepsis (n=27). Results. CD64 and CD163 MFI measured on neutrophils and monocytes were elevated in patients withSIRS with sepsis. Diagnostic accuracy of indexes was equal to diagnostic accuracy of MFI for CD64 on neutrophils (0.833 versus 0.854 for day 0 and 0.975 versus 0.983 for day 1) and monocytes (0.811 versus 0.865 for day 0 and 0.825 versus 0.858 for day 1), and CD163 on neutrophils (0.595 versus 0.655 for day 0 and 0.677 versus 0.750 for day 1), but not for CD163 on monocytes. Conclusion. CD64 MFI, CD163 MFI, CD64 indexes for neutrophils and monocytes, and CD163 index for neutrophils can all be used for discrimination of SIRS andsepsis in critically ill neonates and children. CD64 index for neutrophils,however, is superior to all other markers.
    Vir: Mediators of inflammation [Elektronski vir]. - ISSN 1466-1861 ([202646], 2008, [str. 1-10])
    Vrsta gradiva - e-članek
    Leto - 2008
    Jezik - angleški
    COBISS.SI-ID - 24439769
    DOI

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