VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Bisoprolol vs. carvedilol in elderly patients with heart failure : rationale and design of the CIBIS-ELD trial
    Düngen, Hans-Dirk ...
    Background: Chronic heart failure (CHF) is a widespread disease with severe quality of life impairment and a poor prognosis. Beta-blockers are the mainstay of CHF therapy; yet they are ... under-prescribed and under-dosed in clinical practice. This is particularly evident in elderly patients, which maybe due to a fear of side-effects or intolerance. Beta-blockers have furthernot been adequately tested in patients with diastolic CHF, which is particularly common in elderly patients. Finally, comparative data on the use of different beta-blockers in patients with CHF is scarce. AIM: To compare thetolerance of bisoprolol and carvedilol in elderly patients with CHF. Methods: CIBIS-ELD is an investigator-initiated, multi-centre, 1:1 randomised,double-blind, phase III trial comparing bisoprolol and carvedilol in patients >/=65 years with systolic or diastolic CHF. Recruitment started inApril 2005 and is anticipated to be completed by April 2008 with at least 800 patients enrolled. Perspective: This is the first large scale head to headbeta-blockers trial in an elderly population with CHF. Besides determiningwhich of two standard beta-blockers is best tolerated in elderly patients with systolic or diastolic CHF, we expect to gain further insight into the treatment of the particular population of patients with diastolic CHF.
    Vir: Clinical research in cardiology. - ISSN 1861-0684 (Letn. 97, št. 9, 2008, str. 578-586)
    Vrsta gradiva - članek, sestavni del
    Leto - 2008
    Jezik - angleški
    COBISS.SI-ID - 24676569
    DOI

vir: Clinical research in cardiology. - ISSN 1861-0684 (Letn. 97, št. 9, 2008, str. 578-586)
loading ...
loading ...
loading ...

Vnos na polico