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  • Protective effects of fullerenol C60(OH)24 against doxorubicin-induced cardiotoxicity and hepatotoxicity in rats with colorectal cancer
    Injac, Rade ...
    The effects of fullerenol C60(OH)24 (Frl) at doses of 25, 50, and 100 mg/kg/week (for a time-span of 3 weeks) on heart and liver tissue after doxorubicin (Dox)-induced toxicity in rats with ... colorectal cancer were investigated. In the present study, we used an in vivo Wistar male rat model to explore whether Frl could protect against Dox-induced (1.5 mg/kg/week for 3weeks) chronic cardio- and hepato- toxicity and compared the effect with a well-known antioxidant, vitamin C (100 mg/kg/week for 3 weeks). According to macroscopic, microscopic, hematological, biochemical, physiological, pharmacological, and pharmacokinetic results, we confirmed that, at all examined doses, Frl exhibits a protective influence on the heart and liver tissue against chronic toxicity induced by Dox.
    Vir: Biomaterials. - ISSN 0142-9612 (Vol. 30, no. 6, 2009, str. 1184-1196)
    Vrsta gradiva - članek, sestavni del
    Leto - 2009
    Jezik - angleški
    COBISS.SI-ID - 2489969

    Povezava(-e):

    http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6TWB-4V22X57-1-1&_cdi=5558&_user=4776866&_orig=browse&_coverDate=02%2F28%2F2009&_sk=999699993&view=c&wchp=dGLbVtz-zSkzk&md5=3168bf3f75cb3f1952eec4cf92929f01&ie=/sdarticle.pdf
    DOI

vir: Biomaterials. - ISSN 0142-9612 (Vol. 30, no. 6, 2009, str. 1184-1196)
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