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Aspects of the progesterone response in Hortaea werneckii : steroid detoxification, protein induction and remodelling of the cell wallKrižančić Bombek, Lidija ...Progesterone in sublethal concentrations temporarily inhibits growth of Hortaea werneckii. This study investigates some of the compensatory mechanismswhich are activated in the presence of ... progesterone and are most probably contributing to escape from growth inhibition. These mechanisms lead on the one hand to progesterone biotransformation/detoxification but, on the other, are suggested to increase the resistance of H. werneckii to the steroid. Biotransformation can detoxify progesterone efficiently in the early logarithmic phase, with mostly inducible steroid transforming enzymes, while progesterone biotransformation/detoxification in the late logarithmic and stationary phases of growth is not very efficient. The relative contribution of constitutive steroid transforming enzymes to progesterone biotransformationis increased in these latter phases of growth. In the presence of progesterone, activation of the cell wall integrity pathway is suggested by the overexpression of Pck2 which was detected in the stationary as well as the logarithmic phase of growth of the yeast. Progesterone treated H. werneckii cells were found to be more resistant to cell lysis than mock treated cells, indicating for the first time changes in the yeast cell wall as a result of treatment with progesterone.Vir: Steroids. - ISSN 0039-128X (Letn. 73, 2008, str. 1465-1474)Vrsta gradiva - članek, sestavni delLeto - 2008Jezik - angleškiCOBISS.SI-ID - 24991705
Avtor
Križančić Bombek, Lidija |
Lapornik, Ajda |
Ukmar, Marjeta |
Matis, Maja |
Črešnar, Bronislava, 1950-2024 |
Peter Katalinić, Jasna |
Žakelj-Mavrič, Marija
Teme
Yeasts |
Growth And Development |
Metabolism |
Progesterone |
Biotransformation |
Metabolic Detoxication, Drug |
Cell Wall |
Fungal Proteins |
Rna, Messenger |
Spectrum Analysis, Mass |
Presnovana detoksikacija zdravila |
Progesteron |
Celična stena |
Kvasovke |
Biotransformacija |
RNA, prenašalna |
Spektralna analiza masna |
Glivične beljakovine
Vnos na polico
Trajna povezava
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Križančić Bombek, Lidija | 24423 |
Lapornik, Ajda | |
Ukmar, Marjeta | |
Matis, Maja | 21493 |
Črešnar, Bronislava, 1950-2024 | 08777 |
Peter Katalinić, Jasna | |
Žakelj-Mavrič, Marija | 03082 |
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