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  • Interferon autoantibodies associated with AIRE deficiency decrease the expression of IFN-stimulated genes
    Kisand, Kai ...
    Neutralizing autoantibodies to type I, but not type II, interferons (IFNs) arefound at high titers in almost every patient with autoimmune polyendocrinopathy candidiasis ectodermal dystrophy ... (APECED), a disease causedby AIRE gene mutations that lead to defects in thymic T-cell selection. Combining genome-wide expression array with real time RT-PCR assays, we here demonstrate that antibodies against IFN-alpha cause highly significant down-regulation of interferon-stimulated gene expression in cells from APECED patients' blood by blocking their highly dilute endogenous IFNs. This down-regulation was lost progressively as these APECED cells matured in cultures without neutralizing autoantibodies. Most interestingly, a rare APECED patient with autoantibodies to IFN-omega but not IFN-alpha showed a marked increase in expression of the same interferon-stimulated genes. We alsoreport unexpected increases in serum CXCL10 levels in APECED. Our resultsargue that the breakdown of tolerance to IFNs in AIRE deficiency is associated with impaired responses to them in thymus, and highlight APECED as another autoimmune disease with associated dysregulation of IFN activity.
    Vir: Blood. - ISSN 0006-4971 (Letn. 112, št. 7, 2008, str. 2657-2666)
    Vrsta gradiva - članek, sestavni del
    Leto - 2008
    Jezik - angleški
    COBISS.SI-ID - 25229017
    DOI

vir: Blood. - ISSN 0006-4971 (Letn. 112, št. 7, 2008, str. 2657-2666)
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