VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
-
Pharmacodynamic Study Using FLT PET/CT in Patients with Renal Cell Cancer and Other Solid Malignancies Treated with Sunitinib MalateLiu, G. ...Purpose : To characterize proliferative changes in tumors during the sunitinib malate exposurežwithdrawal using 3ć-Deoxy-3ć-š18Fđfluorothymidine (FLT) PETžCTimaging. Patients and MethodsČ Patients ... with advanced solid malignanciesand no prior anti-VEGF exposure were enrolled. All patients had metastatic lesions amenable to FLT PETžCT imaging. Sunitinib was initiated at the standard dose of 50 mg PO daily either on a 4ž2 or 2ž1 schedule. FLT PETžCT scans were obtained at baseline, during sunitinib exposure, and after sunitinib withdrawal within cycle #1 of therapy. VEGF levels and sunitinib pharmacokinetic data were assessed at the same time points. ResultsČ 16 patients (8 pts on 4ž2 scheduleč 8 pts on 2ž1 schedule) completed all three planned FLT PETžCT scans, and were evaluable for pharmacodynamic imaging evaluation. During sunitinib withdrawal (change from scan 2 to 3), median FLT PET SUVmean increased +15% (range -14% to +277%) (p=0.047) for the 4ž2 schedule and +19% (range -5.3% to +200%) (p=0.047) for the 2ž1 schedule. Sunitinib PK and VEGF ligand levels increased during sunitinib exposure, and returned towards baseline during the treatment withdrawal. ConclusionsČ The increase of cellular proliferation during sunitinib withdrawal in patients with renal cell carcinoma and other solid malignancies is consistent with a VEGFR TKI withdrawal flare. Univariate and multivariate analysis suggest that plasma VEGF is associated with this flare, with an exploratory analysis implying that patients who experience less clinical benefit have a larger withdrawal flare. This might suggest that patients with a robust compensatory response to VEGFR TKI therapy experience early Ćangiogenic escape.Vir: Clinical cancer research. - ISSN 1078-0432 (Vol. 17, 2011, str. 7634-7641)Vrsta gradiva - članek, sestavni delLeto - 2011Jezik - angleškiCOBISS.SI-ID - 25278759
Avtor
Liu, G. |
Jeraj, Robert |
Vanderhoek, M. |
Perlman, S. B. |
Kolesar, Jill M. |
Harrison, M.R. |
Simončič, Urban, 1981- |
Eickhoff, Jens C. |
Carmichael, L. |
Chao, B. |
Marnocha, R. |
Ivy, P. |
Wilding, G.
Teme
onkologija
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|---|
Liu, G. | |
Jeraj, Robert | 15737 |
Vanderhoek, M. | |
Perlman, S. B. | |
Kolesar, Jill M. | |
Harrison, M.R. | |
Simončič, Urban, 1981- | 27760 |
Eickhoff, Jens C. | |
Carmichael, L. | |
Chao, B. | |
Marnocha, R. | |
Ivy, P. | |
Wilding, G. |
Vir: Osebne bibliografije
in: SICRIS
Izberite prevzemno mesto:
Prevzem gradiva po pošti
Naslov za dostavo:
Med podatki člana manjka naslov.
Storitev za pridobivanje naslova trenutno ni dostopna, prosimo, poskusite še enkrat.
S klikom na gumb "V redu" boste potrdili zgoraj izbrano prevzemno mesto in dokončali postopek rezervacije.
S klikom na gumb "V redu" boste potrdili zgoraj izbrano prevzemno mesto in naslov za dostavo ter dokončali postopek rezervacije.
S klikom na gumb "V redu" boste potrdili zgoraj izbrani naslov za dostavo in dokončali postopek rezervacije.
Obvestilo
Trenutno je storitev za avtomatsko prijavo in rezervacijo nedostopna. Gradivo lahko rezervirate sami na portalu Biblos ali ponovno poskusite tukaj kasneje.
Gesla v Splošnem geslovniku COBISS
Izbira mesta prevzema
Gradivo iz matične enote je brezplačno. Če je gradivo na mesto prevzema dostavljeno iz drugih enot, lahko knjižnica to storitev zaračuna.
Mesto prevzema | Status gradiva | Rezervacija |
---|
Rezervacija v teku
Prosimo, počakajte trenutek.
Rezervacija je uspela.
Rezervacija ni uspela.
Rezervacija...
Članska izkaznica:
Mesto prevzema: