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  • Airway angiogenesis in patients with rhinitis and controlled asthma
    Škrgat, Sabina ...
    Background: Airway angiogenesis may be an important part of structural remodelling in the pathogenesis of asthma. The development of asthma is frequently preceded by rhinitis. Objective: We sought to ... determine whether thelevels of angiogenesis-related factors are elevated in airways of patients with rhinitis or controlled asthma. Methods: We analysed the induced sputum of18 rhinitis patients, 16 asthmatic patients, and 15 healthy controls. The concentrations of angiogenin, vascular endothelial growth factor (VEGF), IL-8,fibroblast growth factor (bFGF), and TNF-alpha were measured by cytometric bead arrays. Results: We found significantly increased angiogenin and VEGF concentrations in the induced sputum supernatant of both rhinitis andasthma patients compared with that of the healthy control group (P< or =0.0005). With the exception of TNF-alpha, there was no difference in the other angiogenic factors; TNF-alpha levels were higher in the rhinitis group than in the control group (P=0.02). Conclusion: These in vivo results suggest increased airway angiogenesis in patients with rhinitis without asthma as wellas in corticosteroid-treated and well-controlled asthma patients.
    Vir: Clinical and experimental allergy. - ISSN 0954-7894 (Letn. 39, št. 3, 2009, str. 354-360)
    Vrsta gradiva - članek, sestavni del
    Leto - 2009
    Jezik - angleški
    COBISS.SI-ID - 25417689
    DOI

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