-
Home-cage activity in heterogeneous stock (HS) mice as a model of baseline activityMill, Jan ...Behavioral genetic work in humans indicates that clinical hyperactivity is best viewed as the extreme end of activity levels in the population. However, current animal models of hyperactivity are not ... studied as quantitative traitsas they are either knockout models or inbred strains. Furthermore, theseanimal models generally demonstrate elevated locomotion in novel environments, but not in their home-cages. This is the opposite of the symptoms seen in the human condition where childhood hyperactivity is generally more pronounced in constant, unstimulating situations. In this studywe filmed an outbred population of 44 heterogeneous stock (HS) mice underred light during their active phase, to assess the reliability of individual differences in home-cage behavior and extract an index of home-cageactivity (HCA) level. We then compared this measure to locomotor behavior in a novel environment--the open-field. Reliable individual differences in home-cage behaviors such as running, swinging on bars, and burrowing were found, and principal component factor analysis yielded a general activity factor, which accounted for 32% of the variance and correlated 0.90 with a subjective impression of activity level. The correlation between HCA and locomotor activity in the open-field was 0.23, which was non-significant. However, the association with HCA level appeared toincrease over the five minutes of the open-field, presumably as the mice habituated. Furthermore, although mice displaying particularly high and low HCA were indistinguishable early in the open-field task, they became significantly differentiated over time. We conclude that home-cage behaviors and the open-field, after habituation, display good face and construct validity, and may provide a good model of baseline activity for quantitative trait loci (QTL) discovery and functional genomics in the HS mice.Vir: Genes, brain and behavior. - ISSN 1601-1848 (Letn. 1, št. 3, 2002, str. 166-173)Vrsta gradiva - članek, sestavni delLeto - 2002Jezik - angleškiCOBISS.SI-ID - 25419225
Avtor
Mill, Jan |
Galsworthy, Michael J., 1976- |
Paya-Cano, Jose L. |
Sluyter, F. |
Schalkwyk, Leonard C. |
Plomin, Robert, 1948- |
Asherson, P.
Teme
Social Environment |
Animals |
Arousal |
Genetics |
Physiology |
Brain |
Physiology |
Crosses, Genetic |
Exploratory Behavior |
Physiology |
Mice |
Models, Genetic |
Motor Activity |
Physiology |
Reference Values |
Socialno okolje |
Živali |
Prebujenje |
Miši |
Možgani |
Preiskovalno vedenje |
Motorična aktivnost |
Križanje genetsko |
Modeli genetski |
Normalne vrednosti
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|---|
Mill, Jan | ![]() |
Galsworthy, Michael J., 1976- | 30505 |
Paya-Cano, Jose L. | ![]() |
Sluyter, F. | ![]() |
Schalkwyk, Leonard C. | ![]() |
Plomin, Robert, 1948- | ![]() |
Asherson, P. | ![]() |
Izberite prevzemno mesto:
Prevzem gradiva po pošti
Obvestilo
Gesla v Splošnem geslovniku COBISS
Izbira mesta prevzema
Mesto prevzema | Status gradiva | Rezervacija |
---|
Prosimo, počakajte trenutek.