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  • The hantaviral load in tissues of naturally infected rodents
    Korva, Miša ...
    Hantaviruses cause a lifelong and asymptomatic infection in naturally infectedhosts as well as in experimentally infected rodents. Understanding theecology and pathogenesis of hantaviruses requires ... an interdisciplinary research approach, which links laboratory experiments with results gained fromfield studies. Although several studies report hantavirus persistence and tissue infection patterns for experimentally infected rodents, field data is very limited. For this reason, the aim of our study was to investigate Puumala, Dobrava and Saaremaa virus RNA loads and tissue infection patterns intheir natural reservoirs. Hantavirus RNA was demonstrated in all tested internal organs and blood samples of 14 naturally infected rodent hosts. However, the concentration of a specific virus differs depending on the virus,the host and the organ tested. Above all, the Dobrava virus showed a considerably higher viral load in all internal organs and blood samples of infected Apodemus flavicollis hosts. Results obtained in the study support thethesis that virus RNA load reaches its peak in the first month after infection, presumably after the virus has spread throughout all internal organs. This also implies that recently infected rodents are more important for transmission of the virus in the community.
    Vir: Microbes and infection. - ISSN 1286-4579 (Letn. 11, št. 3, 2009, str. 344-351)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2009
    Jezik - angleški
    COBISS.SI-ID - 25475801

vir: Microbes and infection. - ISSN 1286-4579 (Letn. 11, št. 3, 2009, str. 344-351)
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