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  • Bacterial toxin-antitoxin gene system as containment control in yeast cells
    Kristoffersen, P. ...
    The potential of a bacterial toxin-antitoxin gene system for use in containment control in eukaryotes was explored. The Escherichia coli relE and relB genes were expressed in the yeast Saccharomyces ... cerevisiae. Expression ofthe relE gene was highly toxic to yeast cells. However, expression of the relB gene counteracted the effect of relE to some extent, suggesting that toxin-antitoxin interaction also occurs in S. cerevisiae. Thus, bacterial toxin-antitoxin gene systems also have potential applications in the control of cell proliferation in eukaryotic cells, especially in those industrial fermentation processes in which the escape of genetically modified cells would be considered highly risky.
    Vir: Applied and environmental microbiology. - ISSN 0099-2240 (Vol. 66, no. 12, 2000, str. 5524-5526)
    Vrsta gradiva - članek, sestavni del
    Leto - 2000
    Jezik - angleški
    COBISS.SI-ID - 25486041

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