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  • Diversity in organization and the origin of gene orders in the mitochondrial DNA molecules of the genus Saccharomyces
    Groth, Casper ; Petersen, Randi Føns ; Piškur, Jure, 1960-2014
    Sequencing of the Saccharomyces cerevisiae nuclear and mitochondrial genomes provided a new background for studies on the evolution of the genomes. In thisstudy, mitochondrial genomes of a number of ... Saccharomyces yeasts were mapped by restriction enzyme analysis, the orders of the genes were determined, and two of the genes were sequenced. The genome organization, i.e., the size, presence of intergenic sequences, and gene order, as well as polymorphism within the coding regions, indicate that Saccharomyces mtDNA molecules are dynamic structures and have undergone numerous changes during their evolution. Since the separation and sexual isolation of different yeastlineages, the coding parts have been accumulating point mutations, presumably in a linear manner with the passage of time. However, the accumulation of other changes may not have been a simple function of time. Larger mtDNA molecules belonging to Saccharomyces sensu stricto yeasts have acquired extensive intergenic sequences, including guanosine-cytosine-rich clusters, and apparently have rearranged the gene order at higher rates than smaller mtDNAs belonging to the Saccharomyces sensu lato yeasts. While within the sensu stricto group transposition has been a predominant mechanism for thecreation of novel gene orders, the sensu lato yeasts could have used both transposition- and inversion-based mechanisms.
    Vir: Molecular biology and evolution. - ISSN 0737-4038 (Letn. 17, št. 12, 2000, str. 1833-1841)
    Vrsta gradiva - članek, sestavni del
    Leto - 2000
    Jezik - angleški
    COBISS.SI-ID - 25486553

vir: Molecular biology and evolution. - ISSN 0737-4038 (Letn. 17, št. 12, 2000, str. 1833-1841)
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