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  • Genetic polymorphisms modifying oxidative stress are associated with disease activity in rheumatoid arthritis patients
    Bohanec Grabar, Petra ...
    Reactive oxygen and nitrogen species are involved in the pathology of rheumatoid arthritis (RA). Polymorphisms in genes coding for superoxide dismutases (SOD2 and SOD3), catalase (CAT), tumor ... necrosis factor-alpha (TNFA)and inducible NO synthase (NOS2A) may influence RA activity. We determined SOD2 Ala-9Val, SOD3 Arg213Gly, CAT C-262T, TNFA G-308A, TNFA C-857Tand NOS2A (CCTTT) (n)polymorphisms in 327 RA patients. Carriers of CAT -262T and TNFA -308A allele had lower mean disease activity score of 28 jointcount (DAS28) values than patients with CAT -262CC and TNFA -308GG genotypes (p = 0.014 and p = 0.046, respectively). Patients with the combination of CAT -262T and TNFA -308A allele had lower mean DAS28 values anda higher probability for low disease activity than non-carriers (p = 0.003,OR = 3.585, 95% CI = 1.538-8.357). Our results suggest that CAT and TNFApolymorphisms alone and in combination influence the activity of RA.
    Vir: Disease markers. - ISSN 0278-0240 (Vol. 26, no. 1, 2009, str. 41-48)
    Vrsta gradiva - članek, sestavni del
    Leto - 2009
    Jezik - angleški
    COBISS.SI-ID - 25801945
    DOI

vir: Disease markers. - ISSN 0278-0240 (Vol. 26, no. 1, 2009, str. 41-48)
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