VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Formation of G-wires : the role of G:C-base pairing and G-quartet stacking
    Ilc, Tina ...
    G-wires - long, continuous G-quadruplexes - are a promising element for use in nanotechnology, particularly in molecular electronics. The pairing of G-quadruplex structures through complementary ... GC-termini was tested. We designed four analogous G-quadruplex-forming oligonucleotides with the same core sequence d(GGTG4TGG) and with different number and position of GC-ends. We used circular dichroism to determine the topology and relative orientation of G-quadruplexes, 1H NMR to identify Watson-Crick base pairing, and dynamic light scattering to examine the size of the G-quadruplex assemblies. The quadruplexes associated through GC-base pairs forming (G:C:G:C)-quartets and by stacking of unhindered terminal (G:G:G:G)-quartets. These two modes of association had different specificities: stacking occurred at both the 5'- and 3'- faces of the quadruplex, whereas GC-base pairing occurred only at the 5'-face of the quadruplex. These insights may be employed to design G-quadruplex-based nanowires or more complex architectures.
    Vir: The journal of physical chemistry. C, Nanomaterials and interfaces. - ISSN 1932-7447 (Vol. 117, iss. 44, 2013, str. 23208-23215)
    Vrsta gradiva - članek, sestavni del
    Leto - 2013
    Jezik - angleški
    COBISS.SI-ID - 2606436
    DOI

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