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  • Erythropoietin promotes hippocampal neurogenesis in in-vitro models of neonatal stroke
    Osredkar, Damjan ...
    The hippocampus is often injured in neonatal stroke. We have investigated the effect of erythropoietin (EPO) on oxygen-glucose deprived hippocampal slices and hypoxic progenitor cells. EPO improved ... survival of the organotypic hippocampal slices with significantly less cell death in the dentate gyrus andan increased number of proliferating cells 4-5 days after insult. Significantly fewer markers of neurogenesis were seen after the insult but when EPO was added to the culture medium, neurogenesis was sustained. When hippocampal progenitor cultures were stimulated into differentiation, more cells chose a neuronal cell fate when treated with EPO. These findings supportthe hypothesis that EPO not only prevents ischemia induced cell death but promotes neuronal cell fate committment in in-vitro models of neonatal stroke.
    Vir: Neurobiology of disease. - ISSN 0969-9961 (iss. 2, Vol. 38, May 2010, str. 259-265)
    Vrsta gradiva - članek, sestavni del
    Leto - 2010
    Jezik - angleški
    COBISS.SI-ID - 26507737
    DOI

vir: Neurobiology of disease. - ISSN 0969-9961 (iss. 2, Vol. 38, May 2010, str. 259-265)
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