VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • 2-aminothiazoles in drug discovery : privileged structures or toxicophores?
    Jakopin, Žiga
    The 2-aminothiazole functionality has long been established as a privileged structural feature and therefore frequently exploited in the process of drug discovery and development. It has been ... introduced into numerous compounds due to its capacity for targeting a wide range of therapeutic target proteins. On the other hand, the aminothiazole group has also been classified as a toxicophore susceptible to metabolic activation and the ensuing reactive metabolite formation, hence caution is warranted when used in drug design. This review is divided into three parts entailing: (i) the general characteristics of the aminothiazole group, (ii) the advantages of the aminothiazole group in medicinal chemistry, and (iii) the impact of the integrated aminothiazole group on compound safety profile.
    Vir: Chemico-biological interactions. - ISSN 0009-2797 (Vol. 330, 2020, str. 1-8)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2020
    Jezik - angleški
    COBISS.SI-ID - 26594819

    Povezava(-e):

    https://www.sciencedirect.com/science/article/pii/S000927972030987X
    DOI

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