VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Adipocytokines are associated with renal function in patients with normal range glomerular filtration rate and type 2 diabetes
    Pongrac Barlovič, Draženka ; Zaletel, Jelka ; Preželj, Janez
    Introduction: Adipocytokines represent a molecular link between metabolic factors and vascular function. The purpose of our study was to investigate therelationship between adiponectin, leptin and ... renal function parameters in patients with glomerular filtration rate (GFR) above 90 ml/min/m(2) and type 2diabetes. Materials and methods: In 52 patients, plasma (P-) and urinary (U-) adiponectin and leptin were determined by radioimmunoassay and ELISA, respectively. Kidney function was assessed with GFR (plasma iohexol clearance)and albuminuria (radioimmunoassay). Results: The patients were aged 58+/-8 years and had a mean BMI value of 31.2+/-5.2 kg/m(2). Our measurementsyielded the following values, expressed as median (25th percentile, 75th percentile): P-adiponectin 11.0 (7.1, 14.5) microg/ml, P-leptin 20.7 (9.6, 35.9)ng/ml, U-adiponectin 0.8 (0.3, 1.2) microg/mg creatinine, and U-leptin 1.0 (0.4, 1.9) microg/mg creatinine. Albuminuria correlated with P-adiponectin (R=-0.31, p=0.03), and GFR correlated with U-leptin (R=-0.32, p=0.04). Conclusions: Adiponectin and leptin are associatedwith parameters of renal function already at the stage of apparentlynormal kidney function in type 2 diabetes. The exact mechanisms of the adipocyte-vasculature axis still remain to be elucidated.
    Vir: Cytokine. - ISSN 1043-4666 (Letn. 46, št. 1, 2009, str. 142-145)
    Vrsta gradiva - članek, sestavni del
    Leto - 2009
    Jezik - angleški
    COBISS.SI-ID - 26735577
    DOI

vir: Cytokine. - ISSN 1043-4666 (Letn. 46, št. 1, 2009, str. 142-145)
loading ...
loading ...
loading ...

Vnos na polico