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Vaccination of healthy subjects and autoantibodies : from mice through dogs to humansToplak, Nataša, pediatrija, 1967- ; Avčin, TadejVaccination against pathogenic microorganisms is one of the major achievementsof modern medicine, but due to an increasing number of reports of adverse reactions the vaccination procedure has induced ... also considerable debate. It is well known that certain infections are involved in triggering the production of autoantibodies, which could lead to autoimmune adverse reactions in genetically predisposed subjects. Based on these findings it was assumed that vaccinations might induce similar autoimmune reactions. At present there is no clear-cut evidence that vaccinations are associated with overt autoimmune diseases but it has been demonstrated that in genetically predisposed persons vaccination can trigger the production of autoantibodies and autoimmune adverse reactions. The first studies investigating the production of autoantibodies following vaccination were done in dogs and mice.Several studies investigated the production of autoantibodies following vaccination in patients with autoimmune diseases, but there are only limited data on the autoimmune responses after vaccinations in apparently healthy humans. This review summarizes current evidence on the vaccination-induced autoantibodies in apparently healthy subjects including studies in animals andhumans.Vir: Lupus. - ISSN 0961-2033 (Letn. 18, št. 13, 2009, str. 1186-1191)Vrsta gradiva - članek, sestavni delLeto - 2009Jezik - angleškiCOBISS.SI-ID - 26794201
Avtor
Toplak, Nataša, pediatrija, 1967- |
Avčin, Tadej
Teme
Autoimmune Diseases |
Etiology |
Immunology |
Animals |
Autoantibodies |
Immunology |
Dog Diseases |
Etiology |
Immunology |
Dogs |
Mice |
Vaccination |
Adverse Effects |
Avtoimunske bolezni |
Živali |
Avtoprotitelesa |
Pes, bolezni |
Miši |
Psi |
Cepljenje
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Toplak, Nataša, pediatrija, 1967- | 28571 |
Avčin, Tadej | 19258 |
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