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  • Bone tissue engineering with human stem cells
    Marolt Presen, Darja ; Knežević, Miomir ; Vunjak-Novakovic, Gordana
    Treatment of extensive bone defects requires autologous bone grafting or implantation of bone substitute materials. An attractive alternative has been to engineer fully viable, biological bone grafts ... in vitro by culturing osteogenic cells within three-dimensional scaffolds, under conditions supporting bone formation. Such grafts could be used for implantation, but also as physiologically relevant models in basic and translational studies of bone development, disease and drug discovery. A source of human cells that canbe derived in large numbers from a small initial harvest and predictably differentiated into bone forming cells is critically important for engineeringhuman bone grafts. We discuss the characteristics and limitations of various types of human embryonic and adult stem cells, and their utility for bone tissue engineering.
    Vir: Stem cell research & therapy. - ISSN 1757-6512 (Letn. 1, 2010, str. 1-10)
    Vrsta gradiva - e-članek
    Leto - 2010
    Jezik - angleški
    COBISS.SI-ID - 27069657

    Povezava(-e):

    http://stemcellres.com/content/pdf/scrt10.pdf
    DOI

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