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Interacting roles of immune mechanisms and viral load in the pathogenesis of Crimean-Congo Hemorrhagic FeverSaksida, Ana, mikrobiologija ...Until now, the pathogenesis of Crimean-Congo hemorrhagic fever (CCHF) has not been well described. However, it has been hypothesized that it could be a result of the direct injury of virus-infected ... tissues in combination with theindirect effects of host immune responses, including cytokines. To shed more light on the role of viral load and cytokines, differential influences of CCHF virus (CCHFV) RNA load, antibody response, and cytokine production on severity and outcome of the disease were studied in sera of 46 patients with confirmed acute CCHF from Kosovo. In this study, viral load proved to be strongly related to the severity and outcome of the disease, with higher viralloads detected in patients with fatal outcomes than in surviving patients. Also, patients with fatal outcome had on average a weaker antibody response, if one was present at all. High levels of interleukin-10 (IL-10), gamma interferon (IFN-gamma), and tumor necrosis factor alpha (TNF-alpha) wereassociated with poor outcome, since detected concentrations were highest in patients with fatal outcome and lowest in patients with moderate disease course. Additionally, a positive linear dependence between viral load and these cytokines was observed. Interestingly, reduced levels of IL-12 were detected in all CCHF patients. Our study favors the hypothesis that CCHF couldbe a result of a delayed and downregulated immune response caused by IL-10, which leads to an increased replication and spread of CCHFV throughout the body. This consequently triggers increased production of IFN-gamma and TNF-alpha, cytokines mediating vascular dysfunction, disseminated intravascular coagulation, organ failure, and shock.Vir: Clinical and vaccine immunology. - ISSN 1556-6811 (Letn. 17, št. 7, 2010, str. 1086-1093)Vrsta gradiva - članek, sestavni delLeto - 2010Jezik - angleškiCOBISS.SI-ID - 27118553
Avtor
Saksida, Ana, mikrobiologija |
Duh, Darja |
Wraber-Herzog, Branka |
Dedushaj, Iusuf |
Ahmeti, Salih |
Avšič-Županc, Tatjana
Teme
Hemorrhagic Fever, Crimean |
Immunology |
Virology |
Viral Load |
Hemorrhagic Fever Virus, Crimean-Congo |
Interleukin-10 |
Interleukin-12 |
Interferon Type Ii |
Tumor Necrosis Factor |
Rna, Viral |
Fatal Outcome |
Hemoragična mrzlica,virus, Krim-Kongo |
Virusna obremenitev |
Interlevkin-10 |
Interlevkin-12 |
Hemoragična mrzlica krimska |
Inteferon tip II |
Tumor nekrotizirajoči faktor |
Smrtni izid |
RNA virusna
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Saksida, Ana, mikrobiologija | 24279 |
Duh, Darja | 21334 |
Wraber-Herzog, Branka | 04890 |
Dedushaj, Iusuf | ![]() |
Ahmeti, Salih | ![]() |
Avšič-Županc, Tatjana | 10331 |
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