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  • Manganese superoxide dismutase gene polymorphism (V16A) is not associated with myocardial infarction in Slovene type 2 diabetic patients
    Arko, Matevž ; Cilenšek, Ines ; Petrovič, Danijel, 1963-
    Aim: to investigate an association between the V16A MnSOD gene polymorphism and myocardial infarction (MI) in Slovene type 2 diabetic patients. Patients and methods: in this case-control ... cross-sectional study a relationship betweenthe alanine/valine single nucleotide polymorphism (SNP) at amino acid sequence 16 of manganese superoxide dismutase (Mn-SOD) gene and myocardial infarction (MI) in Slovene type 2 diabetic patients was evaluated. Results: the V16A polymorphism of the Mn-SOD gene was analysed in 449 subjects with type 2 diabetes lasting more than 10 years: 159 with MI (diabetics with MI) and 290 diabetics with no history of CAD. The VV genotype of the V16A Mn-SOD SNP was not associated with MI in Slovene patients with type 2 diabetes (OR = 0.9; 95 % CI = 0.6-1.5; P = 0.7). Conclusion: the V16A Mn-SOD SNP might not beused as a genetic marker for MI in Slovene type 2 diabetic patients.
    Vir: Acta medica saliniana : internacionalni časopis = an international journal. - ISSN 0350-364X (Letn. 38, št. 2, 2009, str. 76-80)
    Vrsta gradiva - članek, sestavni del
    Leto - 2009
    Jezik - angleški
    COBISS.SI-ID - 27305433

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