VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • In silico discovery of 2-amino-4-(2,4-dihydroxyphenyl)thiazoles as novel inhibitors of DNA gyrase B
    Brvar, Matjaž ...
    Cyclothialidines are a class of bacterial DNA gyrase B (GyrB) subunit inhibitors, targeting its ATP-binding site. Starting from the available structural information on cyclothialidine GR122222X (2), ... an in silico virtual screening campaign was designed combining molecular docking calculations with three-dimensional structure-based pharmacophore information. A novel class of 2-amino-4-(2,4-dihydroxyphenyl)thiazole based inhibitors (5-9) with low micromolar antigyrase activity was discovered.
    Vir: Bioorganic & Medicinal Chemistry Letters. - ISSN 0960-894X (vol. 20, iss. 3, 2010, str. 958-962)
    Vrsta gradiva - članek, sestavni del
    Leto - 2010
    Jezik - angleški
    COBISS.SI-ID - 2731377

    Povezava(-e):

    https://www.sciencedirect.com/science/article/abs/pii/S0960894X09017831?via%3Dihub
    DOI

Vnos na polico