VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Lovastatin prevents carcinogenesis in a rat model for liver cancer. Effects of ubiquinone supplementation
    Björkhem-Bergman, Linda ...
    Aim: This study tests the hypothesis that statins (HMGCoA reductase inhibitors) inhibit carcinogenesis and that this effect may be mediated by thestatin-induced inhibition of ubiquinone synthesis. ... Materials and methods: The effects of lovastatin, with and without addition of ubiquinone, were studied in a rat model for chemically induced hepatocarcinogenesis. Intermediates in the mevalonate pathway were measured. Results: Lovastatin treatment reduced the volume fraction of liver nodules by 50% and the cell proliferation within the liver nodules was reduced to one third. Ubiquinone (Q10) treatment reversed the statin-induced inhibition of cell proliferation. Lathosterol levels were reduced significantly in the statin-treated rats, indicating inhibition of the mevalonate pathway, but cholesterol levels were not affected. Conclusion: Lovastatin inhibits carcinogenesis in a rat model for liver cancer, despite unaffected cholesterol levels. The statin-induced inhibition of cell proliferation may, at least in part, be explained by the inhibition of ubiquinone synthesis.
    Vir: Anticancer research. - ISSN 0250-7005 (Letn. 30, št. 4, 2010, str. 1105-1112)
    Vrsta gradiva - članek, sestavni del
    Leto - 2010
    Jezik - angleški
    COBISS.SI-ID - 27434457

vir: Anticancer research. - ISSN 0250-7005 (Letn. 30, št. 4, 2010, str. 1105-1112)
loading ...
loading ...
loading ...

Vnos na polico