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Lovastatin prevents carcinogenesis in a rat model for liver cancer. Effects of ubiquinone supplementationBjörkhem-Bergman, Linda ...Aim: This study tests the hypothesis that statins (HMGCoA reductase inhibitors) inhibit carcinogenesis and that this effect may be mediated by thestatin-induced inhibition of ubiquinone synthesis. ... Materials and methods: The effects of lovastatin, with and without addition of ubiquinone, were studied in a rat model for chemically induced hepatocarcinogenesis. Intermediates in the mevalonate pathway were measured. Results: Lovastatin treatment reduced the volume fraction of liver nodules by 50% and the cell proliferation within the liver nodules was reduced to one third. Ubiquinone (Q10) treatment reversed the statin-induced inhibition of cell proliferation. Lathosterol levels were reduced significantly in the statin-treated rats, indicating inhibition of the mevalonate pathway, but cholesterol levels were not affected. Conclusion: Lovastatin inhibits carcinogenesis in a rat model for liver cancer, despite unaffected cholesterol levels. The statin-induced inhibition of cell proliferation may, at least in part, be explained by the inhibition of ubiquinone synthesis.Vir: Anticancer research. - ISSN 0250-7005 (Letn. 30, št. 4, 2010, str. 1105-1112)Vrsta gradiva - članek, sestavni delLeto - 2010Jezik - angleškiCOBISS.SI-ID - 27434457
Avtor
Björkhem-Bergman, Linda |
Ačimovič, Jure |
Torndal, Ulla-Britta |
Parini, Paolo |
Eriksson, Lennart C
Teme
Animals |
Anticarcinogenic Agents |
Pharmacology |
Apoptosis |
Drug Effects |
Body Weight |
Drug Effects |
Cholesterol |
Metabolism |
Disease Models, Animal |
Liver |
Anatomy & Histology |
Drug Effects |
Pathology |
Liver Neoplasms, Experimental |
Metabolism |
Pathology |
Prevention & Control |
Lovastatin |
Pharmacology |
Mevalonic Acid |
Metabolism |
Precancerous Conditions |
Drug Therapy |
Metabolism |
Pathology |
Rats |
Rats, Inbred F344 |
Ubiquinone |
Analogs & Derivatives |
Antagonists & |
Holesterol |
Jetra, novotvorbe eksperimentalne |
Prekanceroze |
Telesna teža |
Bolezen, živalski modeli |
Jetra |
Živali |
Ubikinon |
Miši seva F344 |
Podgane |
Antikarcinogeni |
Lovastatin |
Mevalonska kislina |
Apoptoza
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Björkhem-Bergman, Linda | |
Ačimovič, Jure | 28352 |
Torndal, Ulla-Britta | |
Parini, Paolo | |
Eriksson, Lennart C |
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