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Molecular analysis of system N suggests novel physiological roles in nitrogen metabolism and synaptic transmissionChaudhry, Farrukh A ...The amino acid glutamine has a central role in nitrogen metabolism. Although the molecular mechanisms responsible for its transport across cell membranes remain poorly understood, classical amino ... acid transport system N appears particularly important. Using intracellular pH measurements, we have now identified an orphan protein related to a vesicular neurotransmitter transporter as system N. Functional analysis shows that this protein (SN1) involves H+ exchange as well as Na+ cotransport and, under physiological conditions, mediates glutamine efflux as well as uptake. Together with the pattern of SN1 expression, these unusual properties suggest novel physiological roles for system N in nitrogen metabolism and synaptic transmission.Vir: Cell. - ISSN 0092-8674 (Letn. 99, št. 7, 1999, str. 769-780)Vrsta gradiva - članek, sestavni delLeto - 1999Jezik - angleškiCOBISS.SI-ID - 27519193
Avtor
Chaudhry, Farrukh A |
Reimer, Richard J |
Križaj, David |
Barber, Diane
Teme
Amino Acid Sequence |
Animals |
Astrocytes |
Metabolism |
Ultrastructure |
Brain |
Metabolism |
Ultrastructure |
Carrier Proteins |
Genetics |
Metabolism |
Cell Line |
Cloning, Molecular |
Glutamine |
Metabolism |
Hydrogen-Ion Concentration |
Immunohistochemistry |
Membrane Proteins |
Genetics |
Metabolism |
Molecular Sequence Data |
Nitrogen |
Metabolism |
Organ Specificity |
Rats |
Sequence Alignment |
Sodium |
Metabolism |
Synapses |
Metabolism |
Synaptic Transmission |
Physiology |
Celična linija |
Kloniranje molekulsko |
Molekulsko zaporedje, podatki |
Natrij |
Živali |
Imunohistokemija |
Organ, specifičnost |
Membranske beljakovine |
Zaporedje razvrstitev |
Sinaptični prenos |
Možgani |
Nosilne beljakovine |
Dušik |
Podgane |
Astrociti |
Aminokislinsko zaporedje |
Glutamin |
pH |
Sinapse
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Chaudhry, Farrukh A | ![]() |
Reimer, Richard J | ![]() |
Križaj, David | 07133 |
Barber, Diane | ![]() |
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